A bench, a bicycle, and a lake surrounded by trees.
Photo by RVLuckyorWhat
Open Photo by RVLuckyorWhat

Upstate South Carolina Vacations from $271

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Your Upstate South Carolina Vacation

With a Upstate South Carolina vacation package, you can forget about the stress of planning and simply focus on experiencing what this thrilling destination has on offer. With so much to do and see on a trip to Upstate South Carolina, it can be hard to know where to begin. Kick off your travels in Greenville at Falls Park on the Reedy and Bon Secours Wellness Arena — two popular attractions here. Another top city worthy of a spot on your itinerary is Spartanburg. Don't miss WestGate Mall and Tyger River Park. Expedia is your one-stop shop for planning your Upstate South Carolina vacation. From hotels and flights, to car rentals and more, we're here to help you create a travel experience like no other.

The Latest Upstate South Carolina Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • A covered outdoor area with a curved brick pathway leading to a building with a sloped roof.
    Jan 15 - Jan 18

    Fox Run at Lake Lure + Flight

    Lake Lure
    3 nights
    4.5 star property
    9.0/10 - Wonderful (246 reviews)
    "We had a great time!"
    Reviewed November 5, 2026
    Roundtrip • Fort Lauderdale (FLL) - Asheville (AVL)
    FLL - AVL • Nonstop AVL - FLL • Nonstop
    Save 100% on your flight
    $398
    $271
    per traveler
    found 20 hours ago
    Fox Run at Lake Lure
  • A library with bookshelves, a yellow armchair, and a chandelier.
    Jan 15 - Jan 18

    The Restoration Asheville + Flight

    Downtown Asheville
    3 nights
    4.0 star property
    9.8/10 - Exceptional (1,236 reviews)
    "Amazing stay! We really enjoyed it 😻thank you!"
    Reviewed November 7, 2026
    Roundtrip • New York (EWR) - Asheville (AVL)
    EWR - CLT • Nonstop CLT - EWR • Nonstop
    Save 100% on your flight
    $1,027
    $615
    per traveler
    found 1 day ago
    The Restoration Asheville
  • A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a well-lit facade.
    Jan 14 - Jan 18

    Holiday Inn Express & Suites Charlotte NE - University Area by IHG + Flight

    University City
    4 nights
    2.5 star property
    8.6/10 - Excellent (812 reviews)
    Roundtrip • Fort Lauderdale (FLL) - Charlotte (CLT)
    FLL - USA • Nonstop USA - FLL • Nonstop
    $445
    $290
    per traveler
    found 1 day ago
    Holiday Inn Express & Suites Charlotte NE - University Area by IHG
  • A modern living room with a flat-screen TV, a glass coffee table, and a sofa.
    Dec 17 - Dec 22

    Joinery West + Flight

    Optimist Park
    5 nights
    4.0 star property
    7.2/10 - Good (20 reviews)
    "My girlfriend and I loved our stay. The room was clean, cozy, and comfortable. We had a great experience and would stay again."
    Reviewed November 2, 2026
    Roundtrip • Miami (MIA) - Charlotte (CLT)
    MIA - CLT • Nonstop CLT - MIA • Nonstop
    $672
    $450
    per traveler
    found 5 hours ago
    Joinery West
  • A hotel with a covered entrance, stone pillars, and a clock tower.
    Jan 7 - Jan 11

    Holiday Inn Express Hotel and Suites Kings Mountain by IHG + Flight

    Kings Mountain
    4 nights
    2.5 star property
    8.6/10 - Excellent (641 reviews)
    Roundtrip • Fort Lauderdale (FLL) - Charlotte (CLT)
    FLL - CLT • Nonstop CLT - FLL • Nonstop
    $452
    $305
    per traveler
    found 1 hour ago
    Holiday Inn Express Hotel and Suites Kings Mountain by IHG

Discover the most popular places to visit in Upstate South Carolina

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)
Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.
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What to do in Upstate South Carolina

Greenville Haunted Bar Tour

Greenville Haunted Bar Tour

$35
per adult
100% of travelers recommend
Greenville Haunted Bar Tour
See all activities in Upstate South Carolina

Upstate South Carolina Hotel Deals

A modern lobby with a reception desk, seating area, and a television screen.

Best Western Spartanburg I-26

Best Western Spartanburg I-26
2.0 star property
21.9 mi from Upstate South Carolina
9.0 out of 10, Wonderful, (88 reviews)
$93 nightly
The price is $103
Nov 15 - Nov 16
Total with taxes and fees
Best Western Spartanburg I-26
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Upstate South Carolina
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.