Upstate South Carolina Vacations from $465
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Your Upstate South Carolina Vacation
With a Upstate South Carolina vacation package, you can forget about the stress of planning and simply focus on experiencing what this thrilling destination has on offer. With so much to do and see on a trip to Upstate South Carolina, it can be hard to know where to begin. Kick off your travels in Greenville at Falls Park on the Reedy and Bon Secours Wellness Arena — two popular attractions here. Another top city worthy of a spot on your itinerary is Spartanburg. Don't miss WestGate Mall and Tyger River Park. Expedia is your one-stop shop for planning your Upstate South Carolina vacation. From hotels and flights, to car rentals and more, we're here to help you create a travel experience like no other.
The Latest Upstate South Carolina vacation packages
Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn Asheville Downtown
Downtown Asheville
Save 100% on your flight
Price was $767, price is now $465 per person
$465
per person
Mar 6 - Mar 9
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Asheville (AVL)
9.2/10 Wonderful! (895 reviews)
The minute I walked in I was greeted by the nicest employee named Meraldo. He was extremely helpful and appreciated how he made our stay relaxing. Every hotel needs employees like Meraldo
Reviewed on Dec 14, 2025
Cedar Crest Inn
Kenilworth
Save 100% on your flight
Price was $838, price is now $504 per person
$504
per person
Mar 6 - Mar 9
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Asheville (AVL)
9.4/10 Exceptional! (373 reviews)
Room was very clean and cozy. The staff was very cordial and pleasant. The house was beautiful with lots of dark wood interior.
Reviewed on Dec 11, 2025
The Horse Shoe Farm
Save 100% on your flight
Price was $1,182, price is now $760 per person
$760
per person
Mar 6 - Mar 9
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Asheville (AVL)
9.6/10 Exceptional! (7 reviews)
Every staff member went out of his/her way to make us more comfortable.
Reviewed on Jul 27, 2024
Tru by Hilton Charlotte Airport Lake Pointe
Save 100% on your flight
Price was $760, price is now $504 per person
$504
per person
Feb 1 - Feb 8
found 20 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Charlotte (CLT)
9.2/10 Wonderful! (1,112 reviews)
Everything was perfect clean and satisfying
Thank you
Reviewed on Dec 6, 2025
The Restoration Asheville
Downtown Asheville
Save 100% on your flight
Price was $845, price is now $572 per person
$572
per person
Mar 6 - Mar 9
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Asheville (AVL)
9.8/10 Exceptional! (984 reviews)
This was my second time staying at The Restoration Hotel, back in 2023 I rated it a 5 Star. This year I noticed a big difference. This hotel has become a party hotel, the last night the music coming from the roof top was unbearable, staying on the 5th floor did not help. The room was vibrating from the music and the conversations were loud. Though the music was turned down at 10 PM so that helped a lot. The Draftsman Bar Lounge, one of my favorite places in Asheville was off limit due to private parties through out my stay, so that was strike two! The breakfast basket on day one was a winner, the following morning the breakfast basket had two very hard biscuits, so we opted to go out to breakfast. The staff continues to be amazing from the receptionist Mary Katherine to the valet Nick and other fellows that were friendly and professional.
Reviewed on Dec 14, 2025
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See all available trips from Columbus to Upstate South Carolina
View all tripsWhere to stay in Upstate South Carolina
Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville Downtown
3 out of top 10 points of interest in this area
5/5(654 area reviews)
The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.
Discover the most popular places to visit in Upstate South Carolina
Clemson University
5/5(410 reviews)
Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.
Falls Park on the Reedy
4.5/5(583 reviews)
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.
Memorial Stadium
5/5(129 reviews)
Catch an event at Memorial Stadium during your trip to Clemson. Experience the area's theater scene or attend a football game.
What to do in Upstate South Carolina
Epic City Scavenger Hunt in Garden Grove by Operation City Quest
$10
per adult
Greenville Craft Cocktail Tour
$105
per adult
100% of travellers recommend
Upstate South Carolina Hotel Deals
Hilton Greenville
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $109 total per night from Dec 28 to Dec 29
$109 total
Dec 28 - Dec 29
Total with taxes and fees
8.2/10 Very Good! (1,001 reviews)
Amazing staff and clean room
Reviewed on Dec 7, 2025
Homewood Suites by Hilton Greenville Downtown
950 South Main Street Greenville SC
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $135 total per night from Dec 22 to Dec 23
$135 total
Dec 22 - Dec 23
Total with taxes and fees
9.4/10 Exceptional! (1,001 reviews)
All of the above, one of the cleanest, luxurious hotel with many amenities I have stayed in , in along time
Reviewed on Dec 11, 2025
Hyatt Regency Greenville
220 N Main St Greenville SC
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $153 total per night from Dec 22 to Dec 23
$153 total
Dec 22 - Dec 23
Total with taxes and fees
8.6/10 Excellent! (1,010 reviews)
The room was very clean, but the curtains did have what looked like brown finger print stains and the comforter had a small yellow staib. I spoke with one housekeeper that was kind, the man I spoke with at the desk was OK. I was accommodated with my early check in, but I did not get the higher floor ...
Reviewed on Dec 14, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Upstate South Carolina Vacation Packages
Upstate South Carolina Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Charleston Intl. Airport (CHS) |
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.