Upstate South Carolina Vacations from $905
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Your Upstate South Carolina Vacation
With a Upstate South Carolina vacation package, you can forget about the stress of planning and simply focus on experiencing what this thrilling destination has on offer. With so much to do and see on a trip to Upstate South Carolina, it can be hard to know where to begin. Kick off your travels in Greenville at Falls Park on the Reedy and Bon Secours Wellness Arena — two popular attractions here. Another top city worthy of a spot on your itinerary is Spartanburg. Don't miss WestGate Mall and Tyger River Park. Expedia is your one-stop shop for planning your Upstate South Carolina vacation. From hotels and flights, to car rentals and more, we're here to help you create a travel experience like no other.
The Latest Upstate South Carolina vacation packages
Price found within the past 48 hours. Click for updated prices.
The Windsor Boutique Hotel
Downtown Asheville
$1,408
per person
Oct 24 - Oct 29
found 1 day ago
Roundtrip flight included
Boston (BOS) to Asheville (AVL)
9.8/10 Exceptional! (610 reviews)
Perfect stay for my sister and I! Downtown close to everything. Hotel had wonderful service and atmosphere! Small and quaint! Bed was very comfortable!! Having a small kitchen and washer and dryer were very helpful! The bottled water, coffee and snacks were unexpected delights!!
Reviewed on Aug 4, 2026
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View all tripsWhere to stay in Upstate South Carolina
Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville Downtown
2 out of top 10 points of interest in this area
The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.
Nicholtown
If you're spending some time in Nicholtown, Swamp Rabbit Trail and Pleasantburg Shopping Center are top sights worth seeing.
West End
Arts and entertainment thrive in this Greenville neighborhood, with cultural events at the Peace Center and baseball games at Fluor Field at the West End. Don't miss Falls Park on the Reedy and the picturesque Liberty Bridge crossing the river.
Overbrook Historic District
While Overbrook Historic District might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Beattie House and Bon Secours Wellness Arena.
Hampton-Pinckney Historic District
Hampton-Pinckney Historic District is well-liked for its historic sites. If you'd like to do some sightseeing in the greater Greenville area, you might plan a trip to The Children’s Museum of the Upstate or The Peace Center.
Stay near popular Upstate South Carolina attractions
Clemson University
9.6/10 (1,439 reviews)
Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.
Falls Park on the Reedy
9.6/10 (2,661 reviews)
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.
Photo by Karyn Thompson
Fred W. Symmes Chapel
9.8/10 (29 reviews)
You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area.
Bon Secours Wellness Arena
8.6/10 (1,219 reviews)
Catch an event at Bon Secours Wellness Arena during your trip to Greenville. Stroll along the riverfront or experience the acclaimed theater scene in this family-friendly area.
Greenville Convention Center
8.4/10 (571 reviews)
Learn about the events happening at Greenville Convention Center during your trip to Greenville. Attend a sporting event or visit the shops in this family-friendly area.
Haywood Mall
8.8/10 (1,681 reviews)
During your trip to Greenville, you can browse for the perfect souvenirs at Haywood Mall. Experience the great live music or attend a sporting event in this family-friendly area.
Memorial Stadium
9.6/10 (410 reviews)
Catch an event at Memorial Stadium during your trip to Clemson. Experience the area's theater scene or attend a football game.
What to do in Upstate South Carolina
Upstate South Carolina Hotel Deals
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd Greenville SC
Fully refundable
$97 nightly
$108 total
Sep 6 - Sep 7
Total with taxes and fees
8.6/10 Excellent! (1,011 reviews)
"Amazing stay ❤️ Will be staying again!"
Reviewed on Aug 5, 2026
Hyatt Regency Greenville
220 N Main St Greenville SC
Fully refundableReserve now, pay when you stay
$157 nightly
$172 total
Aug 16 - Aug 17
Total with taxes and fees
8.8/10 Excellent! (1,008 reviews)
"All good"
Reviewed on Aug 7, 2026
Hyatt Place Greenville/Haywood
40 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$82 nightly
$91 total
Aug 14 - Aug 15
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Upstate South Carolina Vacation Packages
Upstate South Carolina Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Charleston Intl. Airport (CHS) |
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- Converse College
- Hatcher Garden and Woodland Preserve
- Morgan Square
- Adults Only Vacation Packages Upstate South Carolina
- Spartanburg Expo Center
- Lemans Karting
- Shipwreck Cove
- Golden Lanes and Golden Skate
- Bmw Performance Center
- Bmw Zentrum
- Where to stay in Upstate South Carolina
- Hub City Railroad Museum
- Westgate Mall
- Younts Center for Performing Arts
- Discovery Island Water Park
- Simpsonville Vacations
- Tyger River Park
- Frankie's Fun Park
- Gravitopia Trampoline Arena
- Jerry Richardson Indoor Stadium
- Spartanburg Memorial Auditorium
- Walnut Grove Plantation
- Fred W. Symmes Chapel
- The Showroom Gallery and Performance Hall
- Wofford College
- Spartanburg Regional History Museum
- Musgrove Mill State Historic Site
- Spartanburg Methodist College
- Heritage Park
- 295 Sports Complex
- Spartanburg Vacations
- Falls Park on the Reedy
- Routes Rental Cars in Upstate South Carolina
- Rental cars Greenville-Spartanburg Intl. airport
- Economy Rent a Car Rental Cars in Upstate South Carolina
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- Mex Rent A Car Rental Cars in Upstate South Carolina
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
